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Multiple Choice

In the initial presentation of leukemia, fever and weakness are most often due to what?

Leukemia disrupts normal bone marrow function, so white blood cell production drops and neutropenia (along with other cytopenias) develops. With fewer neutrophils and immune defenses, infections become common and are a major driver of fever. The systemic illness from infection also causes weakness. So fever and weakness at the initial presentation are most often due to secondary infection, not diet deficiency, autoimmune anemia, or radiation exposure.

Leukemia disrupts normal bone marrow function, so white blood cell production drops and neutropenia (along with other cytopenias) develops. With fewer neutrophils and immune defenses, infections become common and are a major driver of fever. The systemic illness from infection also causes weakness. So fever and weakness at the initial presentation are most often due to secondary infection, not diet deficiency, autoimmune anemia, or radiation exposure.