Which mediators are released in the early phase of an asthma attack?

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Multiple Choice

Which mediators are released in the early phase of an asthma attack?

In the early phase of an asthma attack, the airway’s sensitized mast cells release mediators quickly after allergen exposure. The key substances released are histamine, prostaglandins, and leukotrienes. These agents cause rapid bronchoconstriction, increased vascular permeability, and mucus production, leading to the immediate wheezing and coughing seen at the onset. Eosinophils are more linked to the late-phase inflammatory response and chronic asthma, while bradykinin and interleukin-2 are not the primary players driving the immediate bronchoconstrictive events.

In the early phase of an asthma attack, the airway’s sensitized mast cells release mediators quickly after allergen exposure. The key substances released are histamine, prostaglandins, and leukotrienes. These agents cause rapid bronchoconstriction, increased vascular permeability, and mucus production, leading to the immediate wheezing and coughing seen at the onset. Eosinophils are more linked to the late-phase inflammatory response and chronic asthma, while bradykinin and interleukin-2 are not the primary players driving the immediate bronchoconstrictive events.

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