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Multiple Choice

Which phase of an asthma attack is characterized by eosinophil involvement and occurs hours after exposure?

Two phases describe how asthma inflammation unfolds after exposure. The early phase happens within minutes and is driven mainly by mast cell degranulation, releasing histamine and other mediators that cause rapid bronchoconstriction and edema. The late phase develops hours later and is marked by the recruitment and activation of inflammatory cells, especially eosinophils, guided by cytokines like IL-5. Eosinophils contribute to ongoing airway obstruction, mucus production, and tissue damage, extending and intensifying symptoms after the initial attack. Because the option describes eosinophil involvement and a timing of several hours after exposure, it fits the late-phase response best.

Two phases describe how asthma inflammation unfolds after exposure. The early phase happens within minutes and is driven mainly by mast cell degranulation, releasing histamine and other mediators that cause rapid bronchoconstriction and edema. The late phase develops hours later and is marked by the recruitment and activation of inflammatory cells, especially eosinophils, guided by cytokines like IL-5. Eosinophils contribute to ongoing airway obstruction, mucus production, and tissue damage, extending and intensifying symptoms after the initial attack.

Because the option describes eosinophil involvement and a timing of several hours after exposure, it fits the late-phase response best.